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FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer

26 Jun 2024

Abstract excerpt

Triple-negative breast cancer (TNBC) has limited therapeutic options, is highly metastatic and characterized by early recurrence. Lipid metabolism is generally deregulated in TNBC and might reveal vulnerabilities to be targeted or used as biomarkers with clinical value. Ferroptosis is a type of cell death caused by iron-dependent lipid peroxidation which is facilitated by the presence of polyunsaturated fatty...

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PMID: 38926633
DOI: 10.1038/s44321-024-00090-6

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