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A Brain-Aging Transcriptomic Signature Reclassifies WHO Glioma Grade and Predicts Survival Independently of IDH Status: A Multi-Cohort Study

2026-06-18

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<h4>ABSTRACT</h4> <h4>Background</h4> Despite WHO grade and IDH status, significant survival differences remain in diffuse gliomas. We hypothesized that a brain-aging transcriptomic signature, reflecting neuroinflammation, myeloid infiltration, and synaptic loss, would independently predict survival and allow for molecular reclassification. <h4>Methods</h4> A neurodegeneration score was derived via PCA of brain...

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Literature Corpus work
e0ce2418-40e4-5aa4-979b-e4f0da2eba1f
DOI
10.64898/2026.06.10.26355414
Open publication

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A Brain-Aging Transcriptomic Signature Reclassifies WHO Glioma Grade and Predicts Survival Independently of IDH Status: A Multi-Cohort StudyDOI 10.64898/2026.06.10.26355414
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