Article

Machine characterization of rat toxin responses identifies disease states, tolerance mechanisms and organ to whole-body communication

2018-05-28

Abstract excerpt

<h4>Background</h4> Living organisms are constantly exposed to toxic xenobiotics and have therefore evolved protective responses. In mammals, the liver and kidney play central roles in protecting the organism from xenobiotics, and are at high risk of xenobiotic-induced injury. Liver and kidney damage by drugs and industrial toxins have been extensively studied from both classical histopathologic and biochemical p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e0bf3248-bc7d-5926-a581-8bb5b9008ade
DOI: 10.1101/322446

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Machine characterization of rat toxin responses identifies disease states, tolerance mechanisms and organ to whole-body communicationDOI 10.1101/322446Read

Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammationSemantic proximity Read

Machine Learning and Experimental Validation Identified Ferroptosis Signature and Innovative Biomarkers (ESR1 and GSTZ1) in Liver FibrosisSemantic proximity Read

Utilizing gene co-expression networks with the rat kidney TXG-MAPr tool to enhance safety assessment, biomarker identification and human translationSemantic proximity Read

Characterization of Chemically Induced Liver Injuries Using Gene Co-Expression ModulesSemantic proximity Read

Systems Level Analysis and Identification of Pathways and Networks Associated with Liver FibrosisSemantic proximity Read

Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity.Semantic proximity Read

Repeated toxic injuries of murine liver are tolerated through microsteatosis and mild inflammationSemantic proximity Read

Integrated hepatic ferroptosis gene signature dictates pathogenic features of ferroptosisSemantic proximity Read

Transcriptomics, metabolomics, and in silico drug predictions to prevent or treat liver damage in young and aged burn victimsSemantic proximity Read

Alteration of Liver Cell Function and Proliferation: Differentiation Between Adaptation and ToxicitySemantic proximity Read

Rat Deconvolution as Knowledge Miner for Immune Cell Trafficking from Toxicogenomics DatabasesSemantic proximity Read

Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways.Semantic proximity Read