Transcriptomics, metabolomics, and in silico drug predictions to prevent or treat liver damage in young and aged burn victims

Abstract excerpt

<title>Abstract</title> <p>Burns are a leading cause of morbidity and mortality worldwide, affecting individuals of all ages. Burns induce a systemic response affecting multiple organs where the liver is frequently damaged. Since the liver plays a critical role in metabolic, inflammatory, and immune events, a patient with impaired liver often exhibits poor outcomes. The mortality rate after burns in the elderly p...

Topics

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• Disease Models, Animal
• Drug Design
• Liver
• Liver Diseases, Alcoholic
• Molecular Targeted Therapy
• Protective Factors
• Signal Transduction
• Treatment Outcome

Identifiers and source

Literature Corpus work

3d475645-d53f-5cfb-a4ba-23201839f589

DOI

10.21203/rs.3.rs-2363178/v1