Article

Heterogeneity of NOTCH3 activation mechanisms uncovers therapeutic potential for targeted therapies for CADASIL

2024-11-18

Abstract excerpt

NOTCH3 is a developmental signalling receptor that regulates vascular smooth muscle cell (VSMC) proliferation, maintenance and phenotypic plasticity. Its misregulation is linked to both age-associated and inherited forms of small vessel disease and vascular dementia. CADASIL is a dominantly inherited condition, linked to recurrent stroke and vascular dementia, which is caused by mutations in NOTCH3. The mutations...

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Literature Corpus work: e0b1b4a0-614f-57ef-ae4c-a7d0cc3218ed
DOI: 10.1101/2024.11.17.623993

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