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Article

NOTCH3 is non-enzymatically fragmented in inherited cerebral small-vessel disease.

The Journal of biological chemistry - 14 Feb 2020

Young Kelly Z, Lee Soo Jung, Zhang Xiaojie, Cartee Naw May Pearl, Torres Mauricio, Keep Simon G, Gabbireddy Sairisheel R, Fontana Julia L, Qi Ling, Wang Michael M

Abstract excerpt

The small-vessel disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) arises from mutations in the human gene encoding NOTCH3 and results in vascular smooth muscle cell degeneration, stroke, and dementia. However, the structural changes in NOTCH3 involved in CADASIL etiology are unclear. Here, we discovered site-specific fragmentation of NOTCH3 protein in...

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Source

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Identifiers

PMID: 31901894
DOI: 10.1074/jbc.RA119.007724
PMCID: PMC7029126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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