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Article

CADASIL-causing mutations do not alter Notch3 receptor processing and activation.

Neuroreport - 17 Jul 2006

Low Wee-Chuang, Santa Yo, Takahashi Keikichi, Tabira Takeshi, Kalaria Raj N

Abstract excerpt

CADASIL is associated with mutations in the Notch3 gene but the causal mechanisms of the disorder remain unclear. We studied effects of widely established mutations on Notch3 receptor processing and ligand-mediated activation in stable lines of HEK293 and SH-SY5Y cells expressing either human wild-type or mutant Notch3 receptor. None of the four mutations (R90C, R133C, C185R and R449C) affected quantities of the...

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Identifiers

PMID: 16791082
DOI: 10.1097/01.wnr.0000223394.66951.48

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CADASIL-causing mutations do not alter Notch3 receptor processing and activation.PMID 16791082Read ↗

CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk.Semantic proximity Read ↗

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients.Semantic proximity Read ↗

Heterogeneity of NOTCH3 activation mechanisms uncovers therapeutic potential for targeted therapies for CADASILSemantic proximity Read ↗

A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.Semantic proximity Read ↗

NOTCH3 is non-enzymatically fragmented in inherited cerebral small-vessel disease.Semantic proximity Read ↗

Pathogenic mutations associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy differently affect Jagged1 binding and Notch3 activity via the RBP/JK signaling Pathway.Semantic proximity Read ↗

[CADASIL: genetics and physiopathology].Semantic proximity Read ↗

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild-Type Receptors: Identification of Highly Selective Inhibitors That Block the Process.Semantic proximity Read ↗

Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL.Semantic proximity Read ↗

Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases.Semantic proximity Read ↗

Hypomorphic NOTCH3 alleles do not cause CADASIL in humans.Semantic proximity Read ↗

[Molecular basis and physiopathogenic mechanisms of CADASIL: a model of small vessel diseases of the brain].Semantic proximity Read ↗

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