Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Composition of the Hemagglutinin Polybasic Proteolytic Cleavage Motif Mediates Variable Virulence of H7N7 Avian Influenza Viruses.

Scientific reports - 22 Dec 2016

Abdelwhab E M, Veits Jutta, Ulrich Reiner, Kasbohm Elisa, Teifke Jens P, Mettenleiter Thomas C

Abstract excerpt

Acquisition of a polybasic cleavage site (pCS) in the hemagglutinin (HA) is a prerequisite for the shift of low pathogenic (LP) avian influenza virus (AIV) to the highly pathogenic (HP) form in chickens. Whereas presence of a pCS is required for high pathogenicity, less is known about the effect of composition of pCS on virulence of AIV particularly H7N7. Here, we investigated the virulence of four avian H7N7...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chick Embryo
Share to Chickens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Outbreaks

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza in Birds

Share to Madin Darby Canine Kidney Cells

Share to Poultry

Source

Open in PubMed Open full text

Identifiers

PMID: 28004772
DOI: 10.1038/srep39505
PMCID: PMC5177941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Composition of the Hemagglutinin Polybasic Proteolytic Cleavage Motif Mediates Variable Virulence of H7N7 Avian Influenza Viruses.PMID 28004772Read ↗

Variable impact of the hemagglutinin polybasic cleavage site on virulence and pathogenesis of avian influenza H7N7 virus in chickens, turkeys and ducksSemantic proximity Read ↗

Evidence for Different Virulence Determinants and Host Response after Infection of Turkeys and Chickens with Highly Pathogenic H7N1 Avian Influenza VirusSemantic proximity Read ↗

Different genetic determinants for high virulence, transmission and replication of high pathogenicity H7N7 avian influenza virus in turkeys and chickensSemantic proximity Read ↗

H9 avian influenza reassortant with engineered polybasic cleavage site displays a highly pathogenic phenotype in chickenSemantic proximity Read ↗

Hemagglutinin Subtype Specificity and Mechanisms of Highly Pathogenic Avian Influenza Virus GenesisSemantic proximity Read ↗

Acquisition of a polybasic hemagglutinin cleavage site by a low-pathogenic avian influenza virus is not sufficient for immediate transformation into a highly pathogenic strain.Semantic proximity Read ↗

Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotypeSemantic proximity Read ↗

H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice.Semantic proximity Read ↗

The Neuraminidase Stalk Deletion Serves as Major Virulence Determinant of H5N1 Highly Pathogenic Avian Influenza Viruses in ChickenSemantic proximity Read ↗

Insertion of a Multibasic Cleavage Motif into the Hemagglutinin of a Low-Pathogenic Avian Influenza H6N1 Virus Induces a Highly Pathogenic PhenotypeSemantic proximity Read ↗

Hemagglutinin and neuraminidase of a non-pathogenic H7N7 avian influenza virus coevolved during the acquisition of intranasal pathogenicity in chickens.Semantic proximity Read ↗

Non-basic amino acids in the hemagglutinin proteolytic cleavage site of a European H9N2 avian influenza virus modulate virulence in turkeys.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.