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Article

Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype

30 Jan 2012

Abstract excerpt

High-pathogenic avian influenza viruses (HPAIVs) evolve from low-pathogenic precursors specifying the HA serotypes H5 or H7 by acquisition of a polybasic HA cleavage site. As the reason for this serotype restriction has remained unclear, we aimed to distinguish between compatibility of a polybasic cleavage site with H5/H7 HA only and unique predisposition of these two serotypes for insertion mutations. To this...

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PMID: 22308331
DOI: 10.1073/pnas.1109397109

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