Article

Effects of N-linked glycan of Lassa Virus Envelope Glycoprotein on the Immune Response

2020-09-30

Abstract excerpt

Lassa virus (LASV) belongs to the Mammarenavirus genus (family Arenaviridae) and causes severe hemorrhagic fever in humans. The glycoprotein precursor (GPC) contains eleven N-linked glycans that play essential roles in GPC functionalities such as cleavage, transport, receptor recognition, epitope shielding, and immune response. We used three mutagenesis strategies to abolish the individual glycan chains on the GP...

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Literature Corpus work: e09183b6-ab99-5ea3-97dd-fc2d06fdd354
DOI: 10.1101/2020.09.29.319855

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