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Article

The BRAF V600E/MEK/ERK/METTL3 positive feedback loop regulates autophagy and promotes stemness and invasiveness in glioblastoma via m6A modification.

Journal of experimental & clinical cancer research : CR - 30 Dec 2025

Xie Yuan, Li Yan, Tang Meiqin, Li Zhi, Hu Wanming, Qiu Xiaoling, Wang Changyu, Zou Yunzhi, Lu Jie, Yuan Ze, Chen Furong, Yang Yuanzhong, Lu Chen, Sai Ke, Guo Ying, He Zhenqiang, Duan Hao, Mou Yonggao

Abstract excerpt

BACKGROUND: Epithelioid glioblastoma (GBM) is characterized by its highly aggressive behavior and the presence of the BRAF V600E mutation. However, the impact and underlying mechanisms of the BRAF V600E mutation on GBM stemness and invasiveness are unknown. Dysregulation of N6-methyladenosine (m6A) modification is closely associated with the progression of various cancers. The role of m6A modification in BRAF...

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Identifiers

PMID: 41469702
DOI: 10.1186/s13046-025-03623-0
PMCID: PMC12853985

Genes

BRAF
METTL3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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