Article

Strain-Level Genetic Heterogeneity and Colonization Dynamics Drive Microbiome Therapeutic Efficacy

2025-08-19

Abstract excerpt

Fecal microbiota transplantation (FMT) has shown immunotherapeutic promise across multiple malignancies, yet its clinical efficacy in non-small-cell lung cancer (NSCLC) remains unexplored. Here, we report results from a single-arm trial demonstrating that FMT significantly enhances anti-PD-1 efficacy and prolongs progression-free survival in patients with advanced PD-L1-negative NSCLC. To understand the mechanisti...

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Literature Corpus work: 6ce370e3-5d46-5a04-830e-1df2ff04f3ca
DOI: 10.1101/2025.08.16.25333785

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