Dysregulated Spliceosome Gene Expression May Be a Common Process in Brains of Neurological and Psychiatric Disorders

Abstract excerpt

Alternative splicing (AS) contributes to the increased cellular and functional tissue complexity that is substantial in the brain. AS is tightly regulated because it is critical to many biological processes. Defective splicing is observed in several neurological and psychiatric disorders. While exonic mutations usually affect the splicing of an individual RNA, mutations in the splicing factors (components of splic...

Topics

Open a Topic to create a Post that cites this publication.

• Alternative Splicing
• Central Nervous System
• Databases as Topic
• Gene Expression Regulation, Developmental
• Genomics
• Neurons
• Receptors, GABA
• Receptors, N-Methyl-D-Aspartate

Identifiers and source

Literature Corpus work

e063b74e-a777-544b-9109-9a854d6b9bec

DOI

10.21203/rs.3.rs-1184033/v1