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Real Time <i>In vivo</i> Analysis of Pancreatic Beta-cell Autophagic Flux Reveals Impairment Before Onset of Autoimmune Diabetes

2023-05-23

Abstract excerpt

The catabolic pathway of autophagy is critical for pancreatic beta-cell function and is defective in established type 1 diabetes (T1D). However, it is unclear when and how this critical cell process becomes defective during diabetes pathogenesis. To study the nature of autophagy dysfunction in the context of autoimmune diabetes, we utilized intravital microscopy to study autophagic flux in vivo in real time. We g...

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Literature Corpus work
e0103f84-ef5b-5503-b5dc-bed10d09dca4
DOI
10.1101/2023.05.23.541935
Open publication

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Real Time <i>In vivo</i> Analysis of Pancreatic Beta-cell Autophagic Flux Reveals Impairment Before Onset of Autoimmune DiabetesDOI 10.1101/2023.05.23.541935
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