Article

Multi-omic analyses identify molecular targets of Chd7 that mediate CHARGE syndrome model phenotypes

2025-07-29

Abstract excerpt

CHARGE syndrome is a developmental disorder that affects 1 in 10,000 births, and patients exhibit both physical and behavioral characteristics. De novo mutations in CHD7 (chromodomain helicase DNA binding protein 7) cause 67% of CHARGE syndrome cases. CHD7 is a DNA-binding chromatin remodeler with thousands of predicted binding sites in the genome, making it challenging to define molecular pathways linking loss...

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Literature Corpus work: dfde82be-a592-5b34-8436-f866cff4be58
DOI: 10.1101/2025.07.28.666396

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