Article

Analysis of CHD-7 defective dauer nematodes implicates collagen misregulation in CHARGE syndrome features

2021-03-26

Abstract excerpt

<h4>ABSTRACT</h4> CHARGE syndrome is a complex developmental disorder caused by mutations in the chromodomain helicase DNA-binding protein7 (CHD7) and characterized by retarded growth and malformations in the heart and nervous system. Despite the public health relevance of this disorder, relevant targets of CHD7 that relate to disease pathology are still poorly understood. Here we report that chd-7 , the nematod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d822c73c-ac3a-5599-b0ba-3d638f83f2cf
DOI: 10.1101/2021.03.26.437191

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of CHD-7 defective dauer nematodes implicates collagen misregulation in CHARGE syndrome featuresDOI 10.1101/2021.03.26.437191Read

Multi-omic analyses identify molecular targets of Chd7 that contribute to CHARGE syndrome model phenotypes.Semantic proximity Read

Multi-omic analyses identify molecular targets of Chd7 that mediate CHARGE syndrome model phenotypesSemantic proximity Read

CHD7 regulates craniofacial cartilage development via controlling HTR2B expressionSemantic proximity Read

Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome.Semantic proximity Read

Chromodomain proteins in development: lessons from CHARGE syndromeSemantic proximity Read

The mutation in Chd7 causes misexpression of Bmp4 and developmental defects in telencephalic midline.Semantic proximity Read

Morphological and sensorimotor phenotypes in a zebrafish CHARGE syndrome model are domain-dependentSemantic proximity Read

Clinical and molecular effects of CHD7 in the heart.Semantic proximity Read

Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome.Semantic proximity Read

Kismet/CHD7/CHD8 affects gut biomechanics, the gut microbiome, and gut-brain axis in <i>Drosophila melanogaster</i>Semantic proximity Read

CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance.Semantic proximity Read

The chromatin remodeling protein CHD7, mutated in CHARGE syndrome, is necessary for proper craniofacial and tracheal developmentSemantic proximity Read