Article

Morphological and sensorimotor phenotypes in a zebrafish CHARGE syndrome model are domain-dependent

2022-07-14

Abstract excerpt

CHARGE syndrome is a rare disorder characterized by a spectrum of defects affecting multiple tissues and behavioral difficulties such as autism, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, anxiety, and sensory deficits. Most CHARGE cases arise from de novo , loss-of-function mutations in a master transcriptional regulator, chromodomain-helicase-DNA-binding-protein-7 (CHD7). CHD7 regul...

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Literature Corpus work: ac983e8e-c5cb-5845-8d0d-69e78ddf337e
DOI: 10.1101/2022.07.14.499979

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