Article

Preclinical evaluation of pharmacological inhibition of SIRT1 on the growth of tumoral and metastatic granulosa cells

2024-07-04

Abstract excerpt

<h4>Background</h4> Clinical management of patients with recurrent ovarian granulosa cell tumor (GCT) remains poor. Sirtuin-1 (SIRT1), a deacetylase enzyme involved in the regulation of tumor growth and metastasis, may represent a therapeutic target due to the availability of selective pharmacological inhibitors with minimal toxicity. <h4>Methods</h4> We assessed the possible overexpression of SIRT1 during tumor...

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Literature Corpus work: dfc352c1-d808-5c53-b675-29fd05424491
DOI: 10.1101/2024.07.02.601506

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