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Article

SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis.

Oncogene - 1 Oct 2021

Tan Ping, Wang Manli, Zhong Ailing, Wang Yiyun, Du Jiajia, Wang Jian, Qi Lu, Bi Zhanying, Zhang Peng, Lin Tianhai, Zhang Jiapeng, Yang Lu, Chen Jingyao, Han Ping, Gong Qiyong, Liu Yu, Chen Chong, Wei Qiang

Abstract excerpt

There are unmet clinical needs for novel therapeutic targets and drugs for bladder cancer. Majority of previous work relied on limited bladder cancer cell lines, which could not well represent the tumor heterogeneity and pathology of this disease. Recently, it has been shown that cancer organoids can recapitulate pathological and molecular properties of bladder cancer. Here, we report, by our knowledge, the first...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34471236
DOI: 10.1038/s41388-021-01999-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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