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Article

Computer-aided affinity enhancement of a cross-reactive antibody against dengue virus envelope domain III

2023-01-19

Abstract excerpt

The dengue virus (DENV), composed of four distinct but serologically related Flaviviruses, causes the most important emerging viral disease, with nearly 400 million infections yearly. Currently, there are no approved therapies. Although DENV infection induces lifelong immunity against the same serotype, the antibodies raised contribute to severe disease in heterotypic infections. Therefore, understanding the mecha...

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Literature Corpus work
dfbe5c72-151e-5c79-84cd-379e6c65b518
DOI
10.21203/rs.3.rs-2476042/v1
Open publication

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