Article

Mutation characteristics of the MYC proximal network and its implications for immunotherapy in human cancer

2023-10-05

Abstract excerpt

<h4>Background: </h4> The proximal MYC network (PMN), formed by MYC, related transcription factors, and coregulatory proteins, has been implicated in cancer. However, it is lacking systematic assessment of the effect of the mutation of PMN-related genes on immune checkpoint inhibitor (ICI) response. Methods To explore this, a discovery cohort that patients with whole-exome sequencing (WES) and ICI-treated clinica...

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Literature Corpus work: dfb9b3e0-f100-52dd-9b5f-a98204f6c816
DOI: 10.21203/rs.3.rs-3393683/v1

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