Article

AKT2 modulates astrocytic nicotine responses <i>in vivo</i>

2024-06-01

Abstract excerpt

A greater understanding of the neurobiology of nicotine is needed to reduce or prevent chronic addiction, ameliorate detrimental nicotine withdrawal effects, and improve cessation rates. Nicotine binds and activates two astrocyte-expressed nicotinic acetylcholine receptors (nAChRs), α4β2 and α7. Protein kinase B-β (Pkb-β or Akt2) expression is restricted to astrocytes in mice and humans and is activated by nicotin...

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Literature Corpus work: dfae913d-7d75-555e-bc3d-a382bcf6e4c6
DOI: 10.1101/2024.05.31.596856

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