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Article

Nicotine self-administration impairs hippocampal plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 2002

Abrous Djoher Nora, Adriani Walter, Montaron Marie-Françoise, Aurousseau Catherine, Rougon Geneviève, Le Moal Michel, Piazza Pier Vincenzo

Abstract excerpt

Nicotine, the neuroactive compound responsible for tobacco addiction, is primarily believed to have beneficial effects on the adult brain. However, in heavy smokers, abstinence from nicotine is accompanied by cognitive impairments that suggest adverse effects of nicotine on brain plasticity. For this reason, we studied changes in plasticity-related processes in the dentate gyrus (DG) of the hippocampal formation...

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PMID: 11978841
PMCID: PMC6758344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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