Article

Differential Expression Analysis for Longitudinal Single-Cell RNA-Sequencing Studies Using REBEL

2026-05-11

Abstract excerpt

Longitudinal scRNA-seq experiments offer a powerful approach for dissecting temporal gene expression dynamics in individual cell types. However, few methods have been developed specifically to address the unique statistical challenges of repeated measures in scRNA-seq data. Here, we introduce a novel method, REBEL (Repeated measures Empirical Bayes differential Expression analysis using Linear mixed models), for a...

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Literature Corpus work: dfa2549a-930c-59a6-9143-976274068dc9
DOI: 10.64898/2026.05.06.723139

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