Article

Conservation of C4BP-binding Sequence Patterns in <i>Streptococcus pyogenes</i> M and Enn Proteins

2024-04-22

Abstract excerpt

Antigenically sequence variable M proteins of the major bacterial pathogen Streptococcus pyogenes (Strep A) are responsible for recruiting human C4b-binding protein (C4BP) to the bacterial surface, which enables Strep A to evade destruction by the immune system. The most sequence divergent portion of M proteins, the hypervariable region (HVR), is responsible for binding C4BP. Structural evidence points to the con...

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Literature Corpus work: 9db0188e-39b7-5973-81d8-8303bbfd8d1b
DOI: 10.1101/2024.04.22.590534

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