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Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes

6 Apr 2023

Abstract excerpt

Type 2 diabetes mellitus (T2D) presents a major health and economic burden that could be alleviated with improved early prediction and intervention. While standard risk factors have shown good predictive performance, we show that the use of blood-based DNA methylation information leads to a significant improvement in the prediction of 10-year T2D incidence risk. Previous studies have been largely constrained by...

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PMID: 37117793
DOI: 10.1038/s43587-023-00391-4

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