Integrated analysis reveals the dysfunction of signaling pathways in uveal melanoma

Abstract excerpt

BACKGROUND: Uveal melanoma (UM) is the most common primary intraocular malignancy with a strong tendency to metastasize. The prognosis is poor once metastasis occurs. The treatment remains challenging for metastatic UM, even though our understanding of UM has advanced, mostly because the complexity of the genetic and immunologic background has not been fully explored. METHODS: Single-cell sequencing data were...

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