Article

Proteinase 3 is involved in presepsin production through neutrophil extracellular trap phagocytosis by macrophages

2025-05-03

Abstract excerpt

Presepsin (P-SEP), a soluble subtype of CD14, has been widely reported as a useful biomarker for sepsis in clinical studies. However, the cytological mechanism underlying its production remains poorly understood. Previous research has demonstrated that P-SEP is generated when M1 macrophages (M1 MΦs) phagocytose neutrophil extracellular traps (NETs) and degrade internalized CD14. In this study, we demonstrated that...

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Literature Corpus work: df53dd5b-4381-54b1-b5b4-83e4d9180885
DOI: 10.1101/2025.05.02.651854

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