Article

Photocrosslinking Activity-Based Probes to Capture the Dynamics of Ubiquitin RING E3 Ligase Interactions

2026-03-15

Abstract excerpt

<h4>SUMMARY</h4> Almost all cellular processes are influenced by ubiquitination. A large family of enzymes known as E3 ligases provide the specificity for ubiquitination, with the largest class among them, the RING E3s, comprising over 600 members in humans. RING E3s facilitate transfer of ubiquitin to substrates by constraining the highly dynamic E2-Ub thioester linkage to be primed for attack from the substrate...

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Literature Corpus work: df4704e0-447a-55ca-93da-7736c7a65eea
DOI: 10.64898/2026.03.13.711684

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