Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of high and moderate penetrance monogenic variants, polygenic risk, and family history with breast cancer in an ancestrally diverse population.

Cancer genetics - 1 Jun 2026

Soper Emily R, Casasanta Nicole A, Dubois Bethany, Belbin Gillian M, Kenny Eimear E, Abul-Husn Noura S

Abstract excerpt

Limited data are available on genomic risk factors for breast cancer in diverse populations. We evaluated breast cancer risk conferred by high and moderate penetrance genes, polygenic risk scores (PRS), and family history (FH) in an ancestrally diverse biobank. We identified expected pathogenic variants (EPVs) in 14 genes among 30,223 sequenced individuals, including 15,919 unrelated women. Using electronic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to FH gene

Share to Genetic Predisposition to Disease

Share to Genetic Risk Score

Share to Multifactorial Inheritance

Share to Penetrance

Share to Risk Factors

Source

Identifiers

PMID: 41855952
DOI: 10.1016/j.cancergen.2026.03.004

Genes

FH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of high and moderate penetrance monogenic variants, polygenic risk, and family history with breast cancer in an ancestrally diverse population.PMID 41855952Read ↗

Genetic assessments of breast cancer risk that do not account for polygenic background are incomplete and lead to incorrect preventative strategiesSemantic proximity Read ↗

Development and Validation of a Clinical Polygenic Risk Score to Predict Breast Cancer RiskSemantic proximity Read ↗

Breast and prostate cancer risk: The interplay of polygenic risk, rare pathogenic germline variants, and family history.Semantic proximity Read ↗

Hereditary Breast Cancer: Comprehensive Risk Assessment and Prevention StrategiesSemantic proximity Read ↗

Clinical applications of polygenic breast cancer risk: a critical review and perspectives of an emerging field.Semantic proximity Read ↗

Ancestrally and Temporally Diverse Analysis of Penetrance of Clinical Variants in 72,434 IndividualsSemantic proximity Read ↗

Overlap of high-risk individuals across family history, genetic & non-genetic breast cancer risk models: Analysis of 180,398 women from European & Asian ancestriesSemantic proximity Read ↗

Polygenic risk and rare variant gene clustering enhance cancer risk stratification for breast and prostate cancers.Semantic proximity Read ↗

Development of a Breast Cancer Risk Prediction Model Integrating Monogenic, Polygenic, and Epidemiologic Risk.Semantic proximity Read ↗

Combining rare and common genetic variants improves population risk stratification for breast cancerSemantic proximity Read ↗

Ancestry-specific polygenic risk scores improve clinical assessments of breast cancer risk in diverse populationsSemantic proximity Read ↗

Association of a Polygenic Risk Score With Breast Cancer Among Women Carriers of High- and Moderate-Risk Breast Cancer Genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.