Article

Structural, biophysical and biological analysis and characterisation of IRF4 DNA-binding domain mutations associated with multiple myeloma

2025-03-14

Abstract excerpt

IRF4, a transcription factor in the interferon regulatory factor family, is a key regulator in immune cell differentiation indicated to have an essential role in the development of lymphoid malignancies. Genome-wide association studies previously identified a set of overlapping mutations within the IRF4 DNA-binding domain in T-cell lymphoma and multiple myeloma, several of which appeared to be associated with bett...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: defd5dd6-da88-563c-b735-c019c528d58d
DOI: 10.1101/2025.03.12.642038

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Structural, biophysical and biological analysis and characterisation of IRF4 DNA-binding domain mutations associated with multiple myelomaDOI 10.1101/2025.03.12.642038Read

The molecular basis for the development of adult T-cell leukemia/lymphoma in patients with an IRF4K59R mutation.Semantic proximity Read

A new type of transcriptional reprogramming by an IRF4 mutation in lymphomaSemantic proximity Read

Identification of a PU.1-IRF4 protein interaction surface predicted by chemical exchange line broadening.Semantic proximity Read

AI-driven structural analysis clarifies novel TNFRSF17 variants of uncertain significance as drivers of resistance to BCMA-targeted immunotherapies in multiple myelomaSemantic proximity Read

Effect of novel leukemia mutations (K75E & E222K) on interferon regulatory factor 1 and its interaction with DNA: insights from molecular dynamics simulations and docking studies.Semantic proximity Read

Structure of IRF-3 Bound to the PRDIII-I Regulatory Element of the Human Interferon-β EnhancerSemantic proximity Read

Assessing Interferon Regulatory Factor 4 Complex Formation: Differential Behavior of Homocomplexes Versus Heterocomplexes Induced by Mutations.Semantic proximity Read

Strategies to improve scFvs as crystallization chaperones suggested by analysis of a complex with the human PHD-bromodomain SP140Semantic proximity Read

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.Semantic proximity Read

Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding.Semantic proximity Read

Intrinsic disorder controls two functionally distinct dimers of the master transcription factor PU.1.Semantic proximity Read