Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessing Interferon Regulatory Factor 4 Complex Formation: Differential Behavior of Homocomplexes Versus Heterocomplexes Induced by Mutations.

Biochemistry - 19 Mar 2024

Li Yupeng, Hirano Setoka, Sato Katsuya, Osawa Masatake, Nagaoka Hitoshi

Abstract excerpt

Interferon regulatory factor 4 (IRF4) is a crucial transcription factor that plays a vital role in lymphocyte development, including in the fate-determining steps in terminal differentiation. It is also implicated in the development of lymphoid tumors such as multiple myeloma and adult T-cell leukemia. IRF4 can form a homodimer and multiple heterocomplexes with other transcription factors such as purine-rich box1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Interferon Regulatory Factor-3

Share to Interferon Regulatory Factors

Share to Mutation

Share to Transcription Factor AP-1

Source

Identifiers

PMID: 38439718
DOI: 10.1021/acs.biochem.3c00512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessing Interferon Regulatory Factor 4 Complex Formation: Differential Behavior of Homocomplexes Versus Heterocomplexes Induced by Mutations.PMID 38439718Read ↗

A neomorphic mutation in the interferon activation domain of IRF4 causes a dominant primary immunodeficiency.Semantic proximity Read ↗

IRF4 L116R mutation promotes proliferation of chronic lymphocytic leukemia B cells inducing MYC.Semantic proximity Read ↗

A new type of transcriptional reprogramming by an IRF4 mutation in lymphomaSemantic proximity Read ↗

A conserved homo-dimerization interface in human IFIT1 provides insights into IFIT interactome assemblySemantic proximity Read ↗

Transcriptional reprogramming by mutated IRF4 in lymphomaSemantic proximity Read ↗

The Significance of Tetramerization in Promoter Recruitment by Stat5Semantic proximity Read ↗

Interferon Regulatory Factor 4 (IRF-4) Targets IRF-5 to Regulate Epstein-Barr Virus TransformationSemantic proximity Read ↗

Molecular basis for the functional roles of the multimorphic T95R mutation of IRF4 causing human autosomal dominant combined immunodeficiency.Semantic proximity Read ↗

Effect of novel leukemia mutations (K75E & E222K) on interferon regulatory factor 1 and its interaction with DNA: insights from molecular dynamics simulations and docking studies.Semantic proximity Read ↗

Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers.Semantic proximity Read ↗

Dimerization: a versatile switch for oncogenesisSemantic proximity Read ↗

Crystal structure of epstein-barr virus DNA polymerase processivity factor BMRF1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.