Article

AI-driven structural analysis clarifies novel TNFRSF17 variants of uncertain significance as drivers of resistance to BCMA-targeted immunotherapies in multiple myeloma

2026-01-13

Abstract excerpt

<title>Abstract</title> <p> Background The advent of B-cell maturation antigen (BCMA)-targeted immunotherapies has markedly transformed the prognosis for patients with relapsed/refractory multiple myeloma (r/r MM). However, the emergence of therapeutic resistance, frequently driven by tumor-intrinsic alterations in the <italic>TNFRSF17</italic> (tumor necrosis factor receptor superfamily member 17) gene encod...

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Literature Corpus work: 13646767-3f55-51fe-bc7e-c718cbc12b86
DOI: 10.21203/rs.3.rs-8568919/v1

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AI-driven structural analysis clarifies novel TNFRSF17 variants of uncertain significance as drivers of resistance to BCMA-targeted immunotherapies in multiple myelomaDOI 10.21203/rs.3.rs-8568919/v1Read

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