Article

Cell states beyond transcriptomics: integrating structural organization and gene expression in hiPSC-derived cardiomyocytes

2020-05-27

Abstract excerpt

<h4>Summary</h4> We present a quantitative co-analysis of RNA abundance and sarcomere organization in single cells and an integrated framework to predict subcellular organization states from gene expression. We used human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes expressing mEGFP-tagged alpha-actinin-2 to develop quantitative image analysis tools for systematic and automated classification of s...

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Literature Corpus work: decfe69d-3ef6-5ed2-ab3f-fe2701869cf5
DOI: 10.1101/2020.05.26.081083

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