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Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes

12 Aug 2012

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and is not completely understood. Recent works have demonstrated the importance of microRNAs (miRNAs) in cartilage function. MiRNAs are a class of small noncoding RNAs that regulate gene expression and are...

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PMID: 22883423
DOI: 10.1186/1471-2474-13-144

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