Article
Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody.
Scientific reports - 23 Aug 2024
Jungholm Oscar, Trkulja Carolina, Moche Martin, Srinivasa Sreesha P, Christakopoulou Maria-Nefeli, Davidson Max, Reymer Anna, Jardemark Kent, Fogaça Rafaela Lenza, Ashok Anaswara, Jeffries Gavin, Ampah-Korsah Henry, Strandback Emilia, Andréll Juni, Nyman Tomas, Nouairia Ghada, Orwar Owe
Abstract excerpt
KRAS belongs to a family of small GTPases that act as binary switches upstream of several signalling cascades, controlling proliferation and survival of cells. Mutations in KRAS drive oncogenesis, especially in pancreatic, lung, and colorectal cancers (CRC). Although historic attempts at targeting mutant KRAS with small molecule inhibitors have proven challenging, there are recent successes with the G12C, and...
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