Article
KRAS G12C fragment screening renders new binding pockets.
Small GTPases - 1 Jan 2022
Mathieu Magali, Steier Valérie, Fassy Florence, Delorme Cécile, Papin David, Genet Bruno, Duffieux Francis, Bertrand Thomas, Delarbre Laure, Le-Borgne Hélène, Parent Annick, Didier Patrick, Marquette Jean-Pierre, Lowinski Maryse, Houtmann Jacques, Lamberton Annabelle, Debussche Laurent, Alexey Rak
Abstract excerpt
KRAS genes belong to the most frequently mutated family of oncogenes in cancer. The G12C mutation, found in a third of lung, half of colorectal and pancreatic cancer cases, is believed to be responsible for a substantial number of cancer deaths. For 30 years, KRAS has been the subject of extensive drug-targeting efforts aimed at targeting KRAS protein itself, but also its post-translational modifications,...
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