Article

The Role of Conformational Dynamics in abacavir-Induced Hypersensitivity Syndrome

2017-12-14

Abstract excerpt

Abacavir is an antiretroviral drug used to reduce human immunodeficiency virus (HIV) replication and decrease the risk of developing acquired immune deficiency syndrome (AIDS). However, its therapeutic value is diminished by the fact that it is associated with drug hypersensitivity reactions in up to 8% of treated patients. This hypersensitivity is strongly associated with patients carrying human leukocyte antigen...

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Literature Corpus work: de457686-dbe4-5474-8b3a-4f76db17e219
DOI: 10.1101/234260

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