Comprehensive metabolite ratio QTL mapping reveals disease relevant enzyme biology

Abstract excerpt

Metabolite ratios are valuable proxies for enzyme- and pathway activity, which are otherwise hard to capture. The genetic basis of metabolite ratios has not been systematically studied as it implies expanding the search space quadratically, leading to increased computational burden. Here, we present efficient statistical methodology to identify ratio quantitative trait loci (rQTLs), requiring only association summ...

Topics

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• Arabs
• Cohort Studies
• Consanguinity
• Exome
• High-Throughput Nucleotide Sequencing
• Metabolome
• Middle East
• Quantitative Trait Loci

Identifiers and source

Literature Corpus work

de3158bb-a376-5feb-b109-006f42c8e0cf

DOI

10.64898/2025.12.04.25341616