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Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast.

Genetics - 26 Aug 2021

Garge Riddhiman K, Cha Hye Ji, Lee Chanjae, Gollihar Jimmy D, Kachroo Aashiq H, Wallingford John B, Marcotte Edward M

Abstract excerpt

Thiabendazole (TBZ) is an FDA-approved benzimidazole widely used for its antifungal and antihelminthic properties. We showed previously that TBZ is also a potent vascular disrupting agent and inhibits angiogenesis at the tissue level by dissociating vascular endothelial cells in newly formed blood vessels. Here, we uncover TBZ's molecular target and mechanism of action. Using human cell culture, molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34849907
DOI: 10.1093/genetics/iyab101
PMCID: PMC8633126

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