Back to search

Article

Network Pharmacology-Based Prediction of Anticancer Targets of Mebendazole: Integrating Molecular Targets, Signaling Pathways, and Clinical Evidence

2026-08-24

Abstract excerpt

<title>Abstract</title> <p>Mebendazole (MBZ), a broad-spectrum anthelmintic benzimidazole with an established safety profile, has attracted significant interest as a candidate for oncological drug repurposing. Despite growing preclinical and early clinical evidence, a systematic characterisation of MBZ's multi-target anticancer mechanisms has not been comprehensively performed. Here, we employed a network pharmac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d8a9e905-61e2-59a2-8735-42d1b4ef917f
DOI
10.21203/rs.3.rs-10701477/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Network Pharmacology-Based Prediction of Anticancer Targets of Mebendazole: Integrating Molecular Targets, Signaling Pathways, and Clinical EvidenceDOI 10.21203/rs.3.rs-10701477/v1
Predicting Anticancer Targets of Mebendazole Through Network Pharmacology: An Integrated Analysis of Molecular Targets, Signalling Pathways, and Clinical Trial EvidenceSemantic proximity
Exploring Drug-Target Interactions through Network Pharmacology in Breast cancer: A Text Mining ApproachSemantic proximity
<i>In silico</i> molecular target prediction unveils mebendazole as a potent MAPK14 inhibitorSemantic proximity
In silico Multi-Target Pharmacological Profiling of Itraconazole: Molecular Docking, Binding Free Energy Estimation, and Systems Biology Insights into Potential Anti-Cancer MechanismsSemantic proximity
Identification of crucial genes and biological pathways in lung adenocarcinoma by network pharmacology, molecular docking, and simulation studiesSemantic proximity
BMS345541 is predicted as a repurposed drug for the treatment of TMZ-resistant Glioblastoma using target gene expression and virtual drug screeningSemantic proximity
Targeting dysregulation signatures of p53-MDM2 interactions to identify newer small molecule inhibitors for cancer therapy: Insight from computational directionSemantic proximity
A network pharmacology-based approach and molecular docking study to explore the therapeutic potential of a nutraceutical formula (Vernolac) in the treatment of cancerSemantic proximity
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligandsSemantic proximity
Network-based estimation of therapeutic efficacy and adverse reaction potential for prioritisation of anti-cancer drug combinationsSemantic proximity
A data driven approach to identify ZM-447439 as a potential repurposed drug to overcome tamoxifen-resistance in breast cancerSemantic proximity
Review of Personalized Medicine and Pharmacogenomics of Anti-Cancer Compounds and Natural Products.Semantic proximity
Select a neighboring publication to make it the new centre.