Article

Exploring the Mechanism of Na <sup>+</sup> /K <sup>+</sup> ‑ATPase (NKA) and 20-HETE Ligand Interactions by in-silico modeling

2026-05-15

Abstract excerpt

The Na + /K + -ATPase (NKA) regulates ion balance in the kidney and influences cellular processes like proliferation and apoptosis through its signal transduction. The endogenous ligand 20-Hydroxyeicosatetraenoic acid (20-HETE) contributes to inflammation and fibrosis in chronic kidney disease (CKD) and inhibits NKA activity in renal tubules. However, the molecular mechanism of this interaction remains unclear....

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Literature Corpus work: ddf8df80-3245-5e6a-836d-221826030f46
DOI: 10.64898/2026.05.12.724327

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