Article

Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice

2023-02-09

Abstract excerpt

<h4>Background</h4> Stabilin-1 and Stabilin-2 are two major scavenger receptors of liver sinusoidal endothelial cells that mediate removal of diverse molecules from the plasma. Double-knockout mice (Stab-DKO) develop impaired kidney function and a decreased lifespan, while single Stabilin deficiency or therapeutic inhibition ameliorates atherosclerosis and Stab1-inhibition is subject of clinical trials in immuno-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dde97cd2-f949-5394-87d2-7231f5b26bae
DOI: 10.1101/2023.02.09.526595

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in miceDOI 10.1101/2023.02.09.526595Read

Phenotypical and biochemical characterization of murine psoriasiform and fibrotic skin disease models in Stabilin-deficient mice.Semantic proximity Read

Targeting of scavenger receptors Stabilin-1 and Stabilin-2 ameliorates atherosclerosis by a plasma proteome switch mediating monocyte/macrophage suppressionSemantic proximity Read

Prognostic Values of Stabilin-2 in Hepatocellular CarcinomaSemantic proximity Read

Ectopic expression of the Stabilin2 gene triggered by an intracisternal A particle (IAP) element in DBA/2J strain of mice.Semantic proximity Read

The endothelial scavenger receptor <i>stab2</i> is required for proper hematopoietic stem and progenitor cell development in the fetal blood stem cell nicheSemantic proximity Read

Development of stabilin2+ endothelial cells from mouse embryonic stem cells by inhibition of TGFbeta/activin signaling.Semantic proximity Read

Reduction of Stabilin-2 Contributes to a Protection Against AtherosclerosisSemantic proximity Read

Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling.Semantic proximity Read

Biallelic<i>STAB1</i>pathogenic variants cause hereditary hyperferritinemiaSemantic proximity Read

The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity.Semantic proximity Read

Disruption of the transcription factor recombination signal‐binding protein‐Jκ (RBP‐J) leads to veno‐occlusive disease and interfered liver regeneration in mice†Semantic proximity Read

Hyperfiltration predicts long-term renal outcomes in humanized sickle cell miceSemantic proximity Read