Article
Development of stabilin2+ endothelial cells from mouse embryonic stem cells by inhibition of TGFbeta/activin signaling.
Biochemical and biophysical research communications - 17 Oct 2008
Nonaka Hidenori, Watabe Tetsuro, Saito Shigeru, Miyazono Kohei, Miyajima Atsushi
Abstract excerpt
To understand the endothelial cell (EC) development, arterial, venous, and lymphatic EC (LEC) have been successfully induced from embryonic stem cells (ESC). However, tissue-specific EC, such as hepatic sinusoidal EC (HSEC), have never been generated from ESC. Based on the findings that TGFbeta/activin signaling negatively regulates differentiation of both LEC and HSEC, and that HSEC and LEC are distinguishable...
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