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Article

The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity.

The Journal of clinical investigation - 31 Aug 2018

Swystun Laura L, Lai Jesse D, Notley Colleen, Georgescu Ilinca, Paine A Simonne, Mewburn Jeff, Nesbitt Kate, Schledzewski Kai, Géraud Cyrill, Kzhyshkowska Julia, Goerdt Sergij, Hopman Wilma, Montgomery Robert R, James Paula D, Lillicrap David

Abstract excerpt

Quantitative abnormalities of the von Willebrand factor-factor VIII (VWF-FVIII) complex associate with inherited bleeding or thrombotic disorders. Receptor-mediated interactions between plasma VWF-FVIII and phagocytic or immune cells can influence their hemostatic and immunogenic activities. Genetic association studies have demonstrated that variants in the STAB2 gene, which encodes the scavenger receptor...

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Share to Cell Adhesion Molecules, Neuronal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30124466
DOI: 10.1172/JCI96400
PMCID: PMC6118640

Genes

VWF
STAB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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