Article
Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling.
Peptides - 1 Sept 2011
Arai Takuma, Sakurai Takayuki, Kamiyoshi Akiko, Ichikawa-Shindo Yuka, Iinuma Nobuyoshi, Iesato Yasuhiro, Koyama Teruhide, Yoshizawa Takahiro, Uetake Ryuichi, Yamauchi Akihiro, Yang Lei, Kawate Hisaka, Ogawa Shinichiro, Kobayashi Akira, Miyagawa Shinichi, Shindo Takayuki
Abstract excerpt
Embryonic stem cells (ESCs) are a useful source for various cell lineages. So far, however, progress toward reconstitution of mature liver morphology and function has been limited. We have shown that knockout mice deficient in adrenomedullin (AM), a multifunctional endogenous peptide, or its receptor-activity modifying protein (RAMP2) die in utero due to poor vascular development and hemorrhage within the liver....
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