Article
Ectopic expression of the Stabilin2 gene triggered by an intracisternal A particle (IAP) element in DBA/2J strain of mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2020
Maeda-Smithies Nobuyo, Hiller Sylvia, Dong Sharlene, Kim Hyung-Suk, Bennett Brian J, Kayashima Yukako
Abstract excerpt
Stabilin2 (Stab2) encodes a large transmembrane protein which is predominantly expressed in the liver sinusoidal endothelial cells (LSECs) and functions as a scavenger receptor for various macromolecules including hyaluronans (HA). In DBA/2J mice, plasma HA concentration is ten times higher than in 129S6 or C57BL/6J mice, and this phenotype is genetically linked to the Stab2 locus. Stab2 mRNA in the LSECs was...
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