Article

The differentiation status of luminal-type breast cancer–derived organoids can be altered in vitro through the activation of NOTCH signaling

2022-11-08

Abstract excerpt

<h4>Background: </h4> Drug therapy of luminal-type breast cancer has advanced remarkably; however, its effectiveness continues to be limited by primary and acquired treatment resistance. To identify the means of overcoming such resistance, in vitro disease models that faithfully reproduce the characteristics of original patient tumors must be developed. Although the three-dimensional culturing of breast cancer cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dde86de6-e41c-5767-b1e3-5ecc58d405b2
DOI: 10.21203/rs.3.rs-2232037/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The differentiation status of luminal-type breast cancer–derived organoids can be altered in vitro through the activation of NOTCH signalingDOI 10.21203/rs.3.rs-2232037/v1Read

Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristicsSemantic proximity Read

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineagesSemantic proximity Read

Characterization of organoid cultured human breast cancer.Semantic proximity Read

Breast tumour organoids: promising models for the genomic and functional characterisation of breast cancerSemantic proximity Read

Breast Cancer Organoids Model Patient-Specific Response to Drug TreatmentSemantic proximity Read

Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancerSemantic proximity Read

Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch.Semantic proximity Read

Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunitySemantic proximity Read

Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.Semantic proximity Read

Organoids from Patient Biopsy Samples can Predict the Response of BC Patients to Neoadjuvant ChemotherapySemantic proximity Read

'Normalizing' the malignant phenotype of luminal breast cancer cells via alpha(v)beta(3)-integrin.Semantic proximity Read