Article

Disabling iron uptake and pilus assembly in uropathogenic Escherichia coli using CRISPR-Cas9: a step toward antivirulence therapy

2025-04-28

Abstract excerpt

<title>Abstract</title> Uropathogenic <italic>Escherichia coli</italic> (UPEC) is the leading cause of urinary tract infections (UTIs), driven by virulence factors such as iron acquisition systems and adhesive pili. In this study, we employed CRISPR-Cas9-mediated genome editing to functionally inactivate two critical virulence genes—<italic>iucD</italic>, involved in aerobactin-mediated iron uptake, and <itali...

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Literature Corpus work: 0d0bb22d-c1f8-5084-8808-25d121d06d38
DOI: 10.21203/rs.3.rs-6502856/v1

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