Article
Cataract-causing Y204X mutation of crystallin protein CRYβB1 promotes its C-terminal degradation and higher-order oligomerization.
The Journal of biological chemistry - 1 Aug 2023
Jing Xuping, Zhu Mingwei, Lu Xiaoyun, Wei Ping, Shi Lingyu, Zhang Bu-Yu, Xu Yi, Tang Ya-Ping, Xiang Dao-Man, Gong Peng
Abstract excerpt
Crystallin proteins are a class of main structural proteins of the vertebrate eye lens, and their solubility and stability directly determine transparency and refractive power of the lens. Mutation in genes that encode these crystallin proteins is the most common cause for congenital cataracts. Despite extensive studies, the pathogenic and molecular mechanisms that effect congenital cataracts remain unclear. In...
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